منابع مشابه
Membranes enter transfer negotiations
Genes make their position clear C ertain genes switch their nuclear position in tumor cells, offering a potential new method of diagnosing cancer, say Meaburn et al. Individual genes preferentially localize to specifi c points within the nucleus. The reasons for this aren't known, but the positions can be reshuffled during differentiation. Meaburn et al. wondered whether genes might also rearra...
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Modeling unknown opponents is known as a key factor for the efficiency of automated negotiations. The learning processes are however challenging because of (1) the indirect way the target function can be observed, and (2) the limited amount of experience available to learn from an unknown opponent at a single session. To address these difficulties we propose to adopt two approaches from transfe...
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Polarization transfer is a key experiment for the detection of insensitive nuclei by NMR. Transfer in liquids is often achieved through J-coupling using the INEPT experiment, while in solids the dipolar coupling is used with cross polarization. Liquid crystals, including lipid membranes, are intermediate cases between solids and liquids. In the present article, we compare several transfer metho...
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The ability of nanoparticles (NPs) to be promptly uptaken by the cells makes them both dangerous and useful to human health. It was recently postulated that some NPs might cross the plasma membrane also by a non-endocytotic pathway gaining access to the cytoplasm. To this aim, after having filled mature Xenopus oocytes with Calcein, whose fluorescence is strongly quenched by divalent metal ions...
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Nonviral gene delivery is a promising therapeutic approach because of its safety and controllability, yet limited gene transfer efficacy is a common issue. Most nonviral strategies rely upon endosomal escape designs; however, endosomal escape is often uncorrelated with improved gene transfer and membranolytic structures are typically cytotoxic. Previously, we showed that histone-targeted polypl...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1876iti3